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Gold(I)–Coumarin–Caffeine‐Based Complexes as New Potential Anti‐Inflammatory and Anticancer Trackable Agents
Author(s) -
Trommenschlager Audrey,
Chotard Florian,
Bertrand Benoît,
Amor Souheila,
Richard Philippe,
Bettaïeb Ali,
Paul Catherine,
Connat JeanLouis,
Le Gendre Pierre,
Bodio Ewen
Publication year - 2018
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201800474
Subject(s) - coumarin , caffeine , chemistry , in vitro , fluorophore , anti inflammatory , two photon excitation microscopy , combinatorial chemistry , stereochemistry , biochemistry , pharmacology , fluorescence , medicine , organic chemistry , physics , quantum mechanics , endocrinology
Three new gold(I)–coumarin‐based trackable therapeutic complexes and two non‐trackable analogues have been synthesised and fully characterised. They all display anti‐proliferative properties on several types of cancer cell lines, including those of colon, breast, and prostate. Two complexes displayed significant anti‐inflammatory effects; one displayed pro‐inflammatory behaviour; this highlights the impact of the position of the fluorophore on the caffeine scaffold. Additionally, the three coumarin derivatives could be visualised in vitro by two‐photon microscopy.