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Targeted Delivery of DNA‐Au Nanoparticles across the Blood–Brain Barrier Using Focused Ultrasound
Author(s) -
Chan Tiffany G.,
Morse Sophie V.,
Copping Matthew J.,
Choi James J.,
Vilar Ramon
Publication year - 2018
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201800262
Subject(s) - blood–brain barrier , in vivo , nanoparticle , colloidal gold , nanotechnology , ultrasound , focused ultrasound , materials science , biomedical engineering , medicine , neuroscience , biology , central nervous system , radiology , microbiology and biotechnology
Nanoparticles have been widely studied as versatile platforms for in vivo imaging and therapy. However, their use to image and/or treat the brain is limited, as they are often unable to cross the blood–brain barrier (BBB). To overcome this problem, herein we report the use of focused ultrasound in vivo to successfully deliver DNA‐coated gold nanoparticles to specific locations in the brains of mice.