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Identification of Broad‐Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6‐Diaminopurine Scaffolds
Author(s) -
Kaptein Suzanne J. F.,
Vincetti Paolo,
Crespan Emmanuele,
Rivera Jorge I. Armijos,
Costantino Gabriele,
Maga Giovanni,
Neyts Johan,
Radi Marco
Publication year - 2018
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201800178
Subject(s) - zika virus , dengue virus , dengue fever , virology , antibody dependent enhancement , broad spectrum , flavivirus , arbovirus , outbreak , biology , identification (biology) , virus , serotype , viral replication , antiviral drug , chemistry , combinatorial chemistry , botany
Abstract Social and demographic changes across the world over the past 50 years have resulted in significant outbreaks of arboviruses such as dengue virus (DENV) and Zika virus (ZIKV). Despite the increased threat of infection, no approved drugs or fully protective vaccines are available to counteract the spread of DENV and ZIKV. The development of “broad‐spectrum” antivirals (BSAs) that target common components of multiple viruses can be a more effective strategy to limit the rapid emergence of viral pathogens than the classic “one‐bug/one‐drug” approach. Starting from previously identified multitarget DENV inhibitors, herein we report the identification of novel 2,6‐diaminopurine derivatives that are able to block the replication of both Zika virus and all serotypes of dengue virus (DENV 1–4) in infected cells.