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Niclosamide, a Drug with Many (Re)purposes
Author(s) -
Kadri Hachemi,
Lambourne Olivia A.,
Mehellou Youcef
Publication year - 2018
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201800100
Subject(s) - niclosamide , repurposing , drug , nitazoxanide , wnt signaling pathway , drug repositioning , anthelmintic , drug discovery , pharmacology , neglected tropical diseases , pi3k/akt/mtor pathway , drug development , biology , disease , medicine , bioinformatics , signal transduction , immunology , ecology , biochemistry
Niclosamide is an anthelmintic drug that has been used for over 50 years mainly to treat tapeworm infections. However, with the increase in drug repurposing initiatives, niclosamide has emerged as a true hit in many screens against various diseases. Indeed, from being an anthelmintic drug, it has now shown potential in treating Parkinson's disease, diabetes, viral and microbial infections, as well as various cancers. Such diverse pharmacological activities are a result of niclosamide's ability to uncouple mitochondrial phosphorylation and modulate a selection of signaling pathways, such as Wnt/β‐catenin, mTOR and JAK/STAT3, which are implicated in many diseases. In this highlight, we discuss the plethora of diseases that niclosamide has shown promise in treating.