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Claramines: A New Class Of Broad‐Spectrum Antimicrobial Agents With Bimodal Activity
Author(s) -
Blanchet Marine,
Borselli Diane,
Rodallec Anne,
Peiretti Franck,
Vidal Nicolas,
Bolla JeanMichel,
Digiorgio Carole,
Morrison Kelly R.,
Wuest William M.,
Brunel Jean Michel
Publication year - 2018
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201800073
Subject(s) - antimicrobial , broad spectrum , antibiotics , bacteria , gram negative bacteria , multiple drug resistance , microbiology and biotechnology , biology , gram positive bacteria , drug , gram , cytotoxicity , drug resistance , chemistry , combinatorial chemistry , escherichia coli , pharmacology , biochemistry , in vitro , genetics , gene
The emergence of multidrug‐resistant bacteria and pathogens has created an urgent need for the development of new antibiotics. Herein we report our investigations into the broad‐spectrum activity of an easily prepared water‐soluble polyaminosterol compound, namely claramine A1, against both drug‐sensitive and drug‐resistant Gram‐negative and Gram‐positive bacterial strains. We also report its peculiar mechanism of action, which differs from that of all the other well‐known classes of antibiotics, toward Gram‐negative and Gram‐positive bacteria. Given their low cytotoxicity, this class of compounds based on claramine A1 could constitute an effective response to combat the emergence of multidrug‐resistant bacteria and nosocomial diseases.