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Front Cover: Harnessing the Maltodextrin Transport Mechanism for Targeted Bacterial Imaging: Structural Requirements for Improved in vivo Stability in Tracer Design (ChemMedChem 3/2018)
Author(s) -
Axer Alexander,
Hermann Sven,
Kehr Gerald,
Clases David,
Karst Uwe,
FischerRiepe Lena,
Roth Johannes,
Fobker Manfred,
Schäfers Michael,
Gilmour Ryan,
Faust Andreas
Publication year - 2018
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201800056
Subject(s) - maltodextrin , in vivo , front cover , chemistry , biochemistry , biophysics , biology , cover (algebra) , microbiology and biotechnology , chromatography , mechanical engineering , spray drying , engineering
The Front Cover shows a blueprint of a defined carbohydrate (candy) that is literally devoured by the bacterial cell via maltodextrin transporters. Attaching an imaging label to this carbohydrate allows it to be tracked (yellow shine) and potentially allows sensitive detection and localization of bacterial infection in vivo. The study has identified essential structural features of the tracer molecule to make it less vulnerable to enzymatic degradation (green icons) in the blood. This approach facilitates intracellular accumulation via maltodextrin transporters thereby lightening up the bacterial cell and colony, respectively. More information can be found in the Full Paper by Ryan Gilmour, Andreas Faust et al. on page 241 in Issue 3, 2018 (DOI: 10.1002/cmdc.201700543).