5‐HT 7  Receptor Antagonists with an Unprecedented Selectivity Profile | Zendy

Ates Ali | Zendy; Burssens Pierre | Zendy; Lorthioir Olivier | Zendy; Lo Brutto Patrick | Zendy; Dehon Gwenael | Zendy; Keyaerts Jean | Zendy; Coloretti Francis | Zendy; Lallemand Bénédicte | Zendy; Verbois Valérie | Zendy; Gillard Michel | Zendy; Vermeiren Céline | Zendy

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5‐HT 7 Receptor Antagonists with an Unprecedented Selectivity Profile

Author(s) -

Ates Ali,

Burssens Pierre,

Lorthioir Olivier,

Lo Brutto Patrick,

Dehon Gwenael,

Keyaerts Jean,

Coloretti Francis,

Lallemand Bénédicte,

Verbois Valérie,

Gillard Michel,

Vermeiren Céline

Publication year - 2018

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.201800026

Subject(s) - selectivity , 5 ht receptor , receptor , 5 ht7 receptor , chemistry , serotonin , pharmacology , biology , biochemistry , catalysis

Selective leads : In this study, we generated a new series of serotonin 5‐HT 7 receptor antagonists. Their synthesis, structure–activity relationships, and selectivity profiles are reported. This series includes 5‐HT 7 antagonists with unprecedented high selectivity for the 5‐HT 7 receptor, setting the stage for lead optimization of drugs acting on a range of neurological targets.

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