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Hollow Mesoporous Silica@Metal–Organic Framework and Applications for pH‐Responsive Drug Delivery
Author(s) -
Jia Xiaomin,
Yang Zhiyuan,
Wang Yujun,
Chen Ya,
Yuan Haitao,
Chen Heyin,
Xu Xiaoxiang,
Gao Xueqing,
Liang Zuozhong,
Sun Yu,
Li JianRong,
Zheng Haoquan,
Cao Rui
Publication year - 2018
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201800019
Subject(s) - drug delivery , imidazolate , biocompatibility , doxorubicin , mesoporous silica , zeolitic imidazolate framework , nanotechnology , mesoporous material , chemistry , drug , metal organic framework , materials science , combinatorial chemistry , pharmacology , organic chemistry , adsorption , medicine , surgery , chemotherapy , catalysis
Metal−‐organic frameworks (MOFs), a new type of porous crystalline material, hold great potential in biomedical applications, such as drug delivery. However, the efficacy of drug delivery is limited by low drug loading. In this work, we synthesized hollow mesoporous silica (HMS)@MOF capsules that can be used as a pH‐responsive drug delivery system for the anticancer drug doxorubicin (DOX). DOX is loaded into the inner cavity of HMS. Zeolitic imidazolate framework‐8 (ZIF‐8) nanoparticles are then coated on the outer surface of the DOX‐loaded HMS. The obtained material is a capsule (denoted as DOX/HMS@ZIF), in which DOX is encapsulated. The DOX/HMS@ZIF can be used as an efficient pH‐responsive drug delivery system. DOX is not released under physiological conditions (pH 7.4), but is released at low pH (4–6) from DOX/HMS@ZIF. The DOX/HMS@ZIF capsule shows much higher cytotoxicity than free DOX and alters the delivery pathway for DOX in cancer cells, while the drug‐free HMS@ZIF shows excellent biocompatibility. This opens new opportunities to construct a safe and efficient delivery system for targeted molecules using pH‐responsive release for a wide range of applications.