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Synthesis and Biological Evaluation of Imidazole‐Bearing α‐Phosphonocarboxylates as Inhibitors of Rab Geranylgeranyl Transferase (RGGT)
Author(s) -
Joachimiak Łukasz,
Marchwicka Aleksandra,
GendaszewskaDarmach Edyta,
Błażewska Katarzyna M.
Publication year - 2018
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201700791
Subject(s) - rab , imidazole , chemistry , substituent , stereochemistry , enzyme , gtpase , transferase , ring (chemistry) , structural similarity , structure–activity relationship , biochemistry , in vitro , organic chemistry
Rab geranylgeranyl transferase (RGGT) is an interesting therapeutic target, as it ensures proper functioning of Rab GTPases, a class of enzymes responsible for the regulation of vesicle trafficking. Relying on our previous studies, we synthesized a set of new α‐phosphonocarboxylic acids as potential RGGT inhibitors, with emphasis on the elaboration of imidazole‐containing analogues. We identified two compounds with activity similar to that of previously reported RGGT inhibitors, showing structural similarity to imidazo[1,2‐ a ]pyridine‐containing analogues in terms of their substitution pattern. Interestingly, analogues of the N‐series, derived from another phosphonocarboxylate RGGT inhibitor, 2‐fluoro‐3‐(1 H ‐imidazol‐1‐yl)‐2‐phosphonopropanoic acid, turned out to be inactive in our model, indicating that an additional substituent localized at positions C2 or C4 of the imidazole ring, may adversely affect the potency against the targeted enzyme.