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Front Cover: Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease (ChemMedChem 22/2017)
Author(s) -
Beck Michael W.,
Derrick Jeffrey S.,
Suh JongMin,
Kim Mingeun,
Korshavn Kyle J.,
Kerr Richard A.,
Cho Woo Jong,
Larsen Scott D.,
Ruotolo Brandon T.,
Ramamoorthy Ayyalusamy,
Lim Mi Hee
Publication year - 2017
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201700711
Subject(s) - chemistry , small molecule , pathogenesis , reactive oxygen species , disease , cover (algebra) , front cover , pathological , molecule , radical , neuroscience , nanotechnology , combinatorial chemistry , biochemistry , medicine , biology , materials science , organic chemistry , immunology , pathology , mechanical engineering , engineering
The Front Cover shows the development of small molecules capable of targeting and modulating a variety of pathological elements found in a brain beset with Alzheimer's disease, including metal ions, metal‐free amyloid‐β peptides, metal–amyloid‐β complexes, reactive oxygen species, and free organic radicals. Such compounds can be obtained through rational design that includes minor structural modifications. The studies present that although small molecules are structurally similar, they can interact with distinct pathogenic factors. The overall findings provide the foundation for developing chemical tools that are able to identify the pathogenesis of neurodegenerative diseases. More information can be found in the Full Paper by Ayyalusamy Ramamoorthy, Mi Hee Lim et al. on page 1828 in Issue 22, 2017 (DOI: 10.1002/cmdc.201700456).