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Cover Feature: Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones (ChemMedChem 20/2017)
Author(s) -
Wagman Allan S.,
Cirz Ryan,
McEnroe Glenn,
Aggen James,
Linsell Martin S.,
Goldblum Adam A.,
Lopez Sara,
Gomez Marcela,
Miller George,
Simons Lloyd J.,
Belliotti Thomas R.,
Harris Christina R.,
Poel ToniJo,
Melnick Michael J.,
Gaston Ricky D.,
Moser Heinz E.
Publication year - 2017
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201700624
Subject(s) - chemistry , stereochemistry , protein data bank (rcsb pdb) , pyrrolidine , combinatorial chemistry , ring (chemistry) , trimer , bacteria , bicyclic molecule , organic chemistry , biology , dimer , genetics
The Cover Feature shows the conceptual conversion of clinafloxacin to its tetracyclic analog by addition of a 7‐membered ring, thereby conformationally fixing the amino‐pyrrolidine ring out of plane from the bicyclic quinolone core. The compound is shown bound to one of its targets, topoisomerase IV from S. pneumoniae (PDB 4kpf, I. Laponogov et al., Open Biol . 2016, 6, DOI: 10.1098/rsob.160157) and stacking to its DNA template, depicted schematically in orange. The modification of this fluoroquinolone core resulted in a remarkable enhancement of microbiological potency toward both Gram‐positive and Gram‐negative bacteria. This presents an excellent advantage in our fight against multidrug‐resistant bacteria. More information can be found in the Communication by Heinz E. Moser et al. on page 1687 in Issue 20, 2017 (DOI: 10.1002/cmdc.201700426).