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Inside Cover: 2,6‐Difluorobenzamide Inhibitors of Bacterial Cell Division Protein FtsZ: Design, Synthesis, and Structure–Activity Relationships (ChemMedChem 16/2017)
Author(s) -
Straniero Valentina,
Zanotto Carlo,
Straniero Letizia,
Casiraghi Andrea,
Duga Stefano,
Radaelli Antonia,
De Giuli Morghen Carlo,
Valoti Ermanno
Publication year - 2017
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201700471
Subject(s) - ftsz , antimicrobial , cell division , chemistry , staphylococcus aureus , bacterial cell structure , microbiology and biotechnology , bacillus subtilis , division (mathematics) , mechanism of action , cover (algebra) , bacteria , structure–activity relationship , stereochemistry , antibiotics , combinatorial chemistry , biophysics , cell , biochemistry , in vitro , biology , genetics , mechanical engineering , arithmetic , mathematics , engineering
The inside cover picture shows the general chemical structure of a new class of antimicrobial agents. These antibiotics were designed in order to fight the emerging antimicrobial resistance, thanks to their peculiar and bactericidal mechanism of action: the inhibition of the essential bacterial division protein FtsZ. We defined the structure–activity relationship (SAR) of a series of 3‐(benzodioxan‐2‐yl)‐2,6‐difluorobenzamides, substituted at the 1,4‐benzodioxane or modified at the benzodioxane scaffold, and we tested them for the activity against strains of methicillin‐sensitive or methicillin‐resistant Staphylococcus aureus (MRSA). More information can be found in the Full Paper by Valentina Straniero, Ermanno Valoti et al. on page 1303 in Issue 16, 2017 (DOI: 10.1002/cmdc.201700201).