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Dual‐pH/Magnetic‐Field‐Controlled Drug Delivery Systems Based on Fe 3 O 4 @SiO 2 ‐Incorporated Salecan Graft Copolymer Composite Hydrogels
Author(s) -
Hu Xinyu,
Wang Yongmei,
Zhang Liangliang,
Xu Man,
Zhang Jianfa,
Dong Wei
Publication year - 2017
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201700428
Subject(s) - copolymer , self healing hydrogels , doxorubicin hydrochloride , drug delivery , materials science , chemical engineering , composite number , magnetic nanoparticles , drug carrier , nuclear chemistry , nanoparticle , chemistry , nanotechnology , doxorubicin , polymer chemistry , composite material , polymer , medicine , surgery , engineering , chemotherapy
Salecan is a water‐soluble extracellular β‐glucan and has excellent physicochemical and biological properties for hydrogel preparation. In this study, a new pH/magnetic field dual‐responsive hydrogel was prepared by the graft copolymerization of salecan with 4‐pentenoic acid (PA) and N ‐hydroxyethylacrylamide (HEAA) in the presence of Fe 3 O 4 @SiO 2 nanoparticles for doxorubicin hydrochloride (DOX) release. Integration of Fe 3 O 4 @SiO 2 nanoparticles in salecan‐g‐poly(PA‐co‐HEAA) copolymers afforded magnetic sensitivity to the original material. DOX‐loaded hydrogels exhibited a clear capacity for pH/magnetic field dual‐responsive controlled drug release. Lowering the pH to acidic conditions or introducing an external magnetic field caused an enhancement in DOX release. This salecan‐g‐poly(PA‐co‐HEAA)/Fe 3 O 4 @SiO 2 composite hydrogel is a promising drug carrier for magnetically targeted drug delivery with enhanced DOX cytotoxicity against A549 cells.