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Regulated Drug Release Abilities of Calcium Carbonate–Gelatin Hybrid Nanocarriers Fabricated via a Self‐Organizational Process
Author(s) -
Murai Kazuki,
Kurumisawa Kazuya,
Nomura Yoshihiro,
Matsumoto Mutsuyoshi
Publication year - 2017
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201700358
Subject(s) - nanocarriers , gelatin , drug , calcium carbonate , chemistry , materials science , calcium , nanotechnology , chemical engineering , drug delivery , pharmacology , organic chemistry , medicine , engineering
In this study, we investigated the drug‐releasing behavior of a calcium carbonate (CaCO 3 )–gelatin hybrid nanocarrier, fabricated through a single process using biomimetic mineralization. The organic scaffold (gelatin) of the fabricated nanocarrier is responsible for its capacity to load anionic drugs and for controlling the morphology of the inorganic matrix (CaCO 3 ). We studied the drug‐releasing properties of the nanocarrier by investigating the response of the CaCO 3 matrix to acidic conditions. We found that under neutral conditions, drug release from the nanocarrier was inhibited, whereas under acidic conditions, the drug was efficiently released. Therefore, drug release from the nanocarrier is largely dependent on the surrounding pH.