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Fine and Clean Photothermally Controlled NIR Drug Delivery from Biocompatible Nickel‐bis(dithiolene)‐Containing Liposomes
Author(s) -
Mebrouk Kenny,
Ciancone Mathieu,
Vives Thomas,
CammasMarion Sandrine,
Benvegnu Thierry,
Le GoffGaillard Catherine,
ArlotBonnemains Yannick,
Fourmigué Marc,
Camerel Franck
Publication year - 2017
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201700344
Subject(s) - photothermal therapy , nanocarriers , biocompatible material , singlet oxygen , drug delivery , liposome , nanotechnology , photothermal effect , materials science , chemistry , metal , surface modification , nanoparticle , cytotoxicity , combinatorial chemistry , organic chemistry , oxygen , biomedical engineering , in vitro , biochemistry , medicine
This work demonstrates that metal‐bis(dithiolene) complexes can be efficiently incorporated inside organic nanocarriers and, that under near‐infrared (NIR) irradiation, their high photothermal activity can be finely used to release encapsulated drugs on demand. In contrast to gold nanoparticles and other organic NIR dyes, nickel‐bis(dithiolene) complexes do not produce singlet oxygen under irradiation, a highly desirable characteristic to preserve the chemical integrity and activity of the loaded drug during the NIR‐triggered release from the nanocarriers. Finally, cytotoxicity experiments performed on various cell lines have shown that the incorporation of such metal complexes do not increase the toxicity of the final liposomal formulation. These results offer great promise for the development of innovative biocompatible drug nanocargos that are able to safely deliver their content on demand under NIR laser irradiation. Moreover, this work demonstrates that metal‐bis(dithiolene) complexes, owing to their versatility of functionalization and metal complexation, are attractive photothermal agents for the development of original NIR‐responsive materials for application not only in biotechnology but also in materials science.