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Cover Picture: Novel Pieces for the Emerging Picture of Sulfoximines in Drug Discovery: Synthesis and Evaluation of Sulfoximine Analogues of Marketed Drugs and Advanced Clinical Candidates (ChemMedChem 7/2017)
Author(s) -
Sirvent Juan Alberto,
Lücking Ulrich
Publication year - 2017
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201700179
Subject(s) - drug discovery , front cover , chemistry , combinatorial chemistry , drug , computational biology , pharmacology , medicine , cover (algebra) , biology , biochemistry , engineering , mechanical engineering
The front cover picture shows the general structure of a sulfoximine group in front of a charge density distribution from a computational modeling study, surrounded by a puzzle of tablets that is still being assembled. Sulfoximines, the monoaza‐analogues of sulfones, have been neglected in the life sciences for a long time but have gained considerable recognition as a new and versatile structural motif just recently. The synthetic methodology for sulfoximines has progressed significantly; however, the general understanding of this functional group regarding the medicinal‐chemistry‐relevant properties is still limited. To contribute novel pieces to the emerging picture of sulfoximines in drug discovery, researchers at Bayer AG prepared a set of direct sulfoximine analogues of marketed drugs and advanced clinical candidates to compare the in vitro properties of the matched molecular pairs with respect to biological activity, pharmacokinetics, and physicochemistry. More information can be found in the Full Paper by Ulrich Lücking and Juan Alberto Sirvent on page 487 in Issue 7, 2017 (DOI: 10.1002/cmdc.201700044).