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Benzylphenylpyrrolizinones with Anti‐amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment
Author(s) -
Jourdan JeanPierre,
Since Marc,
El Kihel Laïla,
Lecoutey Cédric,
Corvaisier Sophie,
Legay Rémi,
Sopkováde Oliveira Santos Jana,
Cresteil Thierry,
MalzertFréon Aurélie,
Rochais Christophe,
Dallemagne Patrick
Publication year - 2017
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201700102
Subject(s) - druggability , alzheimer's disease , scavenging , β amyloid , chemistry , disease , amyloid (mycology) , pharmacology , biochemistry , medicine , antioxidant , pathology , inorganic chemistry , gene
Herein we describe the drug design steps developed to increase the radical scavenging and β‐amyloid aggregation inhibitory activities of a previously described series of benzylidenephenylpyrrolizinones. Among the newly synthesized derivatives, some benzylphenylpyrrolizinones exhibited interesting results in regard to those activities. Initial druggability parameters were measured, and suggest these compounds as a suitable starting point for potential alternatives in treating Alzheimer's disease.