Benzylphenylpyrrolizinones with Anti‐amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment

Herein we describe the drug design steps developed to increase the radical scavenging and β‐amyloid aggregation inhibitory activities of a previously described series of benzylidenephenylpyrrolizinones. Among the newly synthesized derivatives, some benzylphenylpyrrolizinones exhibited interesting results in regard to those activities. Initial druggability parameters were measured, and suggest these compounds as a suitable starting point for potential alternatives in treating Alzheimer's disease.