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Back Cover: Characterization of a Cell‐Penetrating Peptide with Potential Anticancer Activity (ChemMedChem 1/2017)
Author(s) -
Gronewold Anja,
Horn Mareike,
Ranđelović Ivan,
Tóvári József,
Muñoz Vázquez Sergio,
Schomäcker Klaus,
Neundorf Ines
Publication year - 2017
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201600624
Subject(s) - peptide , chemistry , cell penetrating peptide , cancer cell , cell , cover (algebra) , biophysics , cancer research , biochemistry , cancer , biology , mechanical engineering , engineering , genetics
The back cover picture shows how the branched cell‐penetrating peptide (CPP), namely (sC18) 2 , effectively enters cancerous cells. Owing to its structural properties, different interactions between cancerous and noncancerous cells occur, leading to obvious different entry pathways. As a result, (sC18) 2 strongly affects cancerous cells and exhibits significant toxic activity to a wide range of different cancer cell types. Moreover, synergistic effects were obtained when combining the CPP with the cytostatic drug actinomycin D. More information can be found in the Full Paper by Ines Neundorf et al. on page 42 in Issue 1, 2017 (DOI: 10.1002/cmdc.201600498).