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Preparation of a Salecan/poly(2‐acrylamido‐2‐methylpropanosulfonic acid‐co‐[2‐(methacryloxy)ethyl]trimethylammonium chloride) Semi‐IPN Hydrogel for Drug Delivery
Author(s) -
Qi Xiaoliang,
Li Junjian,
Wei Wei,
Su Ting,
Zuo Gancheng,
Pan Xihao,
Zhang Jianfa,
Dong Wei
Publication year - 2017
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201600570
Subject(s) - self healing hydrogels , chemistry , drug delivery , polysaccharide , polymer , chloride , glycosidic bond , polymer chemistry , chemical engineering , organic chemistry , enzyme , engineering
Salecan is a water‐soluble bacterial polysaccharide consisting of glucopyranosyl units linked by α‐1,3 and β‐1,3 glycosidic bonds. salecan is suitable for the development of hydrogels for biomedical applications, given its outstanding physicochemical and biological profiles. In this study we designed a new semi‐interpenetrating polymer network hydrogel that introduces the salecan polysaccharide into a stimuli‐responsive poly(2‐acrylamido‐2‐methylpropanosulfonic acid‐co‐[2‐(methacryloxy)ethyl]trimethylammonium chloride) (PAM) hydrogel matrix for controlled insulin release. We found that salecan not only tunes the structure and pore size of the PAM hydrogels, but also endows them with adjustable water release rates. More importantly, in vitro drug loading/release assays demonstrated that insulin is efficiently loaded into the resulting hydrogels and can be released in an on‐demand manner by controlling the pH and salecan dose. Furthermore, cell viability and cell adhesion experiments verified the cell compatibility of these hydrogel carriers. Together, these results make salecan‐incorporated PAM hydrogels promising materials for drug delivery.