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Cover Picture: An Enzyme‐Directed Imidazoquinoline for Cancer Immunotherapy (ChemMedChem 22/2016)
Author(s) -
Hantho Joseph D.,
Strayer Timothy A.,
Nielsen Amy E.,
Mancini Rock J.
Publication year - 2016
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201600561
Subject(s) - immunostimulant , enzyme , immunosurveillance , chemistry , front cover , immunotherapy , immune system , biochemistry , cover (algebra) , cell , immunology , biology , engineering , mechanical engineering
The front cover picture shows an enzyme‐directed pro‐immunostimulant that is converted to an active imidazoquinoline immunostimulant by the action of β‐galactosidase enzyme. The enzyme was appended to the blue B16 melanoma cells (right) and used to drive this conversion. Once the enzyme has removed the galactopyranoside substrate (represented by cheese), the active immunostimulant diffuses away to activate the crimson‐colored innate immune cell in local proximity (left) via bystander effects. This results in a proinflammatory immune response that can be confined, in vitro, to cell cultures containing the enzyme. More information can be found in the Communication by Amy E. Nielsen, Rock J. Mancini, et al. on page 2496 in Issue 22, 2016 (DOI: 10.1002/cmdc.201600443).