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Back Cover: Identification of Ebsulfur Analogues with Broad‐Spectrum Antifungal Activity (ChemMedChem 14/2016)
Author(s) -
Ngo Huy X.,
Shrestha Sanjib K.,
GarneauTsodikova Sylvie
Publication year - 2016
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201600338
Subject(s) - antifungal , broad spectrum , antifungal drugs , chemistry , antifungal drug , pharmacology , mechanism of action , identification (biology) , stereochemistry , combinatorial chemistry , computational biology , in vitro , medicine , biology , biochemistry , microbiology and biotechnology , botany
The back cover picture shows an ebsulfur analogue that displays antifungal activity against various clinically relevant fungal Candida and Aspergillus strains, which are either equivalent or superior to the currently used antifungal drugs. The preliminary antifungal mechanism of action was determined to be correlated with an increase in reactive oxygen species. The safety of this ebsulfur analogue compound was evaluated and found to be comparable with ebselen, an analogous molecule now in clinical trials, in terms of mammalian toxicity. Overall, this work could potentially lead to development of new potent orally active antifungal agents to assist the current antifungal repertoire. More information can be found in the Full Paper by Sylvie Garneau‐Tsodikova et al. on page 1507 in Issue 14, 2016 (DOI: 10.1002/cmdc.201600236).