Premium
Evaluation of Substituted 1,2,3‐Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism
Author(s) -
Asquith Christopher R. M.,
Konstantinova Lidia S.,
Laitinen Tuomo,
Meli Marina L.,
Poso Antti,
Rakitin Oleg A.,
HofmannLehmann Regina,
Hilton Stephen T.
Publication year - 2016
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201600260
Subject(s) - feline immunodeficiency virus , virology , human immunodeficiency virus (hiv) , virus , zinc , chemistry , biology , lentivirus , viral disease , organic chemistry
A diverse library of 5‐thieno‐, 5‐oxo‐, and 5‐imino‐1,2,3‐dithiazole derivatives was synthesized and evaluated for efficacy against the feline immunodeficiency virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed nanomolar activity and low toxicity, representing a potential new class of compounds for the treatment of FIV and HIV.