Evaluation of Substituted 1,2,3‐Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism | Zendy

Asquith Christopher R. M. | Zendy; Konstantinova Lidia S. | Zendy; Laitinen Tuomo | Zendy; Meli Marina L. | Zendy; Poso Antti | Zendy; Rakitin Oleg A. | Zendy; HofmannLehmann Regina | Zendy; Hilton Stephen T. | Zendy

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Evaluation of Substituted 1,2,3‐Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism

Author(s) -

Asquith Christopher R. M.,

Konstantinova Lidia S.,

Laitinen Tuomo,

Meli Marina L.,

Poso Antti,

Rakitin Oleg A.,

HofmannLehmann Regina,

Hilton Stephen T.

Publication year - 2016

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.201600260

Subject(s) - feline immunodeficiency virus , virology , human immunodeficiency virus (hiv) , virus , zinc , chemistry , biology , lentivirus , viral disease , organic chemistry

A diverse library of 5‐thieno‐, 5‐oxo‐, and 5‐imino‐1,2,3‐dithiazole derivatives was synthesized and evaluated for efficacy against the feline immunodeficiency virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed nanomolar activity and low toxicity, representing a potential new class of compounds for the treatment of FIV and HIV.

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