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Polypharmacology in Drug Development: A Minireview of Current Technologies
Author(s) -
Tan Zhi,
Chaudhai Rajan,
Zhang Shuxing
Publication year - 2016
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201600067
Subject(s) - drug development , drug , current (fluid) , drug discovery , drug repositioning , computational biology , computer science , pharmacology , medicine , biology , bioinformatics , engineering , electrical engineering
Polypharmacology, the process in which a single drug is able to bind to multiple targets specifically and simultaneously, is an emerging paradigm in drug development. The potency of a given drug can be increased through the engagement of multiple targets involved in a certain disease. Polypharmacology may also help identify novel applications of existing drugs through drug repositioning. However, many problems and challenges remain in this field. Rather than covering all aspects of polypharmacology, this Minireview is focused primarily on recently reported techniques, from bioinformatics technologies to cheminformatics approaches as well as text‐mining‐based methods, all of which have made significant contributions to the research of polypharmacology.