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Inside Cover: Screening, Synthesis, and In Vitro Evaluation of Vinyl Sulfones as Inhibitors of Complement‐Dependent Cytotoxicity in Neuromyelitis Optica (ChemMedChem 4/2016)
Author(s) -
Ju Eun Ji,
Yeon Seul Ki,
Park JongHyun,
Cheon So Young,
Choi Ji Won,
Ha Taehwan,
Jang Bo Ko,
Kim Siwon,
Kang Yong Gu,
Hwang Hayoung,
Cho Sung Jin,
Cheong Eunji,
Bahn Yong Sun,
Pae Ae Nim,
Kim Sung Min,
Park Ki Duk
Publication year - 2016
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201600046
Subject(s) - neuromyelitis optica , cytotoxicity , chemistry , in vitro , aquaporin 4 , autoantibody , antibody , complement dependent cytotoxicity , complement system , immunology , biochemistry , medicine , antibody dependent cell mediated cytotoxicity
The inside cover picture shows a possible docking pose of a potent small‐molecule compound that has blocking activity against the binding of neuromyelitis optica‐specific immunoglobulin G autoantibodies (NMO‐IgG) and aquaporin 4 (AQP4). Neuromyelitis Optica (NMO) is an autoimmune disorder affecting the optic nerve and spinal cord. NMO pathogenesis involves the binding of NMO‐IgG and AQP4 in astrocytes and complement‐dependent cytotoxicity. A screening system was established for inhibitors against the binding of NMO‐IgG to AQP4 in an in vitro model. More information can be found in the Communication by Sung Min Kim, Ki Duk Park et al. on page 377 in Issue 4, 2016 (DOI: 10.1002/cmdc.201500546).