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Back Cover: Thrombin‐Inhibiting Anticoagulant Liposomes: Development and Characterization (ChemMedChem 3/2016)
Author(s) -
Endreas Wegderes,
Brüßler Jana,
Vornicescu Doru,
Keusgen Michael,
Bakowsky Udo,
Steinmetzer Torsten
Publication year - 2016
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201600032
Subject(s) - thrombin , liposome , chemistry , discovery and development of direct thrombin inhibitors , coagulation , pharmacology , biochemistry , combinatorial chemistry , platelet , immunology , medicine
The back cover picture shows a surface representation of the blood clotting protease thrombin with its positive (blue) and negative (red) electrostatic potential in complex with a specific palmitoylated inhibitor, which is incorporated in the outer membrane of a liposome. The inset represents the binding mode of the inhibitor within the active site of thrombin. Such inhibitor‐containing liposomes possess strong thombin inhibitory potency and anticoagulant activity in plasma. More information can be found in the Full Paper by Torsten Steinmetzer et al. on page 340 in Issue 3, 2016 (DOI: 10.1002/cmdc.201500489).