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Back Cover: Synthesis of 4,4′‐Diaminotriphenylmethanes with Potential Selective Estrogen Receptor Modulator (SERM)‐like Activity (ChemMedChem 8/2015)
Author(s) -
Guedes Gema,
Amesty Ángel,
JiménezMonzón Roberto,
MarreroAlonso Jorge,
Díaz Mario,
FernándezPérez Leandro,
EstévezBraun Ana
Publication year - 2015
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201590025
Subject(s) - selective estrogen receptor modulator , estrogen receptor , antiestrogen , chemistry , cover (algebra) , estrogen , biology , endocrinology , cancer , genetics , mechanical engineering , breast cancer , engineering
The back cover picture shows a diaminetriarylmethane (right, green) with antiestrogenic activity interacting with an estrogen receptor outside the ligand‐binding domain (LBD). The interaction differs from the conventional binding of the antiestrogen 4‐hydroxytamoxifen (left, blue). This suggests that triarylmethanes modulate estrogen‐receptor‐dependent transcriptional activity and cell proliferation by an unconventional mechanism. For further details, see the Full Paper by Leandro Fernández‐Pérez, Ana Estévez‐Braun, et al. on p. 1403 ff.