Premium
Inside Cover: Synthesis, Chiral Separation, Absolute Configuration Assignment, and Biological Activity of Enantiomers of Retro‐1 as Potent Inhibitors of Shiga Toxin (ChemMedChem 7/2015)
Author(s) -
Abdelkafi Hajer,
Michau Aurélien,
Clerget Alexandra,
Buisson DavidAlexandre,
Johannes Ludger,
Gillet Daniel,
Barbier Julien,
Cintrat JeanChristophe
Publication year - 2015
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201590020
Subject(s) - enantiomer , cover (algebra) , chemistry , virulence , toxin , shiga toxin , absolute configuration , stereochemistry , combinatorial chemistry , biochemistry , gene , mechanical engineering , engineering
The inside cover picture shows Retro‐1, a benzodiazepine that blocks the retrograde transport in host cells of Shiga toxins, the virulence factors produced by pathogenic strains of E. coli responsible for food poisoning and hemolytic uremic syndrome. After synthesis and separation, the S ‐enantiomer was found to be more effective at protecting human cells from Shiga toxins. For further details, see the Communication by Daniel Gillet, Jean‐Christophe Cintrat et al. on p. 1153 ff.