Premium
Inside Cover: Novel 1,4‐Substituted‐1,2,3‐Triazoles as Antitubercular Agents (ChemMedChem 5/2015)
Author(s) -
Altimari Jarrad M.,
Hockey Samantha C.,
Boshoff Helena I.,
Sajid Andaleeb,
Henderson Luke C.
Publication year - 2015
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201590012
Subject(s) - cover (algebra) , yield (engineering) , combinatorial chemistry , incidence (geometry) , population , chemistry , nanotechnology , medicine , materials science , mathematics , engineering , environmental health , metallurgy , mechanical engineering , geometry
The inside cover picture shows that 30 % of the world population is infected with TB. In 2013, it caused 1.5 million deaths, and the incidence of drug resistance is increasing. TB's prevalence in low‐ and medium‐income countries means that new therapies must be accessed quickly and cheaply. Simple 1,2,3‐triazoles were assembled via click chemistry in high crude purity and in moderate to high yield, and serve as excellent starting points for development of potent therapies. For further details, see the Communication by Luke C. Henderson et al. on p. 787 ff.