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Inside Cover: Structure–Activity Relationship Studies of Amino Acid Substitutions in Radiolabeled Neurotensin Conjugates (ChemMedChem 1/2016)
Author(s) -
Mascarin Alba,
Valverde Ibai E.,
Mindt Thomas L.
Publication year - 2016
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201500582
Subject(s) - neurotensin , conjugate , chemistry , amino acid , neurotensin receptor , in vitro , cover (algebra) , sequence (biology) , peptide sequence , stereochemistry , receptor , combinatorial chemistry , biochemistry , neuropeptide , gene , mathematics , mechanical engineering , mathematical analysis , engineering
The inside cover picture shows that the composition of the amino acid (AA) sequence of a neurotensin‐based radiotracer is crucial to balance its metabolic stability and receptor affinity in order to optimize the tumor targeting capabilities of the conjugate. Evaluation of a set of radiometallated neurotensin derivatives under standardized experimental conditions in vitro enabled, for the first time, a structure–activity relationship study based on the most commonly applied amino acid substitutions reported in the literature. More information can be found in the Full Paper by Thomas L. Mindt et al. on page 102 in Issue 1, 2016 (DOI: 10.1002/cmdc.201500468).