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Cover Picture: Development of Small‐Molecule Trypanosoma brucei N ‐Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode (ChemMedChem 11/2015)
Author(s) -
Spinks Daniel,
Smith Victoria,
Thompson Stephen,
Robinson David A.,
Luksch Torsten,
Smith Alasdair,
Torrie Leah S.,
McElroy Stuart,
Stojanovski Laste,
Norval Suzanne,
Collie Iain T.,
Hallyburton Irene,
Rao Bhavya,
Brand Stephen,
Brenk Ruth,
Frearson Julie A.,
Read Kevin D.,
Wyatt Paul G.,
Gilbert Ian H.
Publication year - 2015
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201500397
Subject(s) - trypanosoma brucei , front cover , small molecule , structural biology , drug discovery , chemistry , enzyme , computational biology , cover (algebra) , biochemistry , stereochemistry , biology , mechanical engineering , engineering , gene
The front cover picture shows the enzyme N‐ myristoyltransferase from the pathogen Trypanosoma brucei . Next to this is an image of the parasite. Also shown are an inhibitor of the protein that we have previously reported (bottom structure) and two novel scaffolds (top structures) that are reported in our paper in this issue. More details can be found in the Full Paper by Ian H. Gilbert et al. on page 1821 in Issue 11, 2015 (DOI: 10.1002/cmdc.201500301).