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Back Cover: Lipopeptide Nanoparticles: Development of Vaccines against Hookworm Parasite (ChemMedChem 10/2015)
Author(s) -
Fuaad Abdullah A. H. Ahmad,
Pearson Mark S.,
Pickering Darren A.,
Becker Luke,
Zhao Guangzu,
Loukas Alex C.,
Skwarczynski Mariusz,
Toth Istvan
Publication year - 2015
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201500390
Subject(s) - lipopeptide , epitope , peptide , peptide vaccine , protease , chemistry , antibody , virology , biology , biochemistry , immunology , enzyme , genetics , bacteria
The back cover picture shows the action of a vaccine candidate against hookworm. B‐cell peptide epitopes derived from hookworm protease Na‐APR‐1 were incorporated into lipid core peptides (structure shown on the right). Proper epitope conformation (β‐sheet and not α‐helix) was found to be crucial for pathogen protein recognition by the antibodies produced. More details can be found in the Full Paper by Mariusz Skwarczynski et al. on page 1647 in Issue 10, 2015 . (DOI: 10.1002/cmdc.201500227 ).