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Inside Cover: 4‐Alkylated Silver–N‐Heterocyclic Carbene (NHC) Complexes with Cytotoxic Effects in Leukemia Cells (ChemMedChem 9/2015)
Author(s) -
Sandtorv Alexander H.,
Leitch Calum,
Bedringaas Siv Lise,
Gjertsen Bjørn Tore,
Bjørsvik HansRené
Publication year - 2015
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201500344
Subject(s) - carbene , chemistry , alkylation , cytotoxicity , alkyl , hl60 , stereochemistry , leukemia , cytotoxic t cell , combinatorial chemistry , medicinal chemistry , organic chemistry , in vitro , biochemistry , biology , catalysis , genetics
The inside cover picture shows two silver–N‐heterocyclic carbene (NHC) complexes with different alkyl side chains at the 4‐position, namely NHC‐1 (methyl, orange) and NHC‐2 (heptyl, green). To accomplish the devised de novo total synthesis, we utilized novel and indispensable synthetic methods recently developed by our group. Both complexes exhibited potent cytotoxicity against two human leukemia cell lines, HL60 (shown) and MOLM‐13, in the micromolar range. More details can be found in the Full Paper by H.‐R. Bjørsvik et al. on page 1522 in Issue 9, 2015 . (DOI: 10.1002/cmdc.201500234 ).