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Back Cover: Position and Length of Fatty Acids Strongly Affect Receptor Selectivity Pattern of Human Pancreatic Polypeptide Analogues (ChemMedChem 11/2014)
Author(s) -
Mäde Veronika,
BellmannSickert Kathrin,
Kaiser Anette,
Meiler Jens,
BeckSickinger Annette G.
Publication year - 2014
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201490043
Subject(s) - moiety , selectivity , receptor , chemistry , peptide , cover (algebra) , stereochemistry , biochemistry , combinatorial chemistry , catalysis , mechanical engineering , engineering
The back cover picture shows the satiety hormone pancreatic polypeptide binding to a comparative model of human Y 4 receptor. At the highlighted positions, diverse saturated fatty acids were systematically introduced via peptide synthesis on solid support. The most promising analogue, containing a propanoyl moiety, exhibited improved receptor selectivity and stability in blood plasma and liver homogenates, thus representing a suitable drug candidate for antiobesity therapy. For more details, see the Full Paper by Annette G. Beck‐Sickinger et al. on p. 2463 ff.