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Cover Picture: Small Molecules that Target the Toxic RNA in Myotonic Dystrophy Type 2 (ChemMedChem 11/2014)
Author(s) -
Nguyen Lien,
Lee JuYeon,
Wong ChunHo,
Zimmerman Steven C.
Publication year - 2014
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201490040
Subject(s) - myotonic dystrophy , rna , small molecule , rna splicing , chemistry , cover (algebra) , nucleus , microbiology and biotechnology , biochemistry , computational biology , genetics , biology , gene , mechanical engineering , engineering
The front cover picture shows small molecules (yellow) entering a diseased cell and then its nucleus. The molecules selectively bind to a toxic CCUG RNA transcript (purple) that causes myotonic dystrophy type 2. Binding by this potential therapeutic agent (structure shown in white) disrupts the MBNL1–rCCUGexp interaction and frees the key alternative splicing regulator MBNL (blue) to perform it normal function. For more details, see the Full Paper by Steven C. Zimmerman et al. on p. 2455 ff.