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Back Cover: Insight into the Interactions between Novel Coumarin Derivatives and Human A 3 Adenosine Receptors (ChemMedChem 10/2014)
Author(s) -
Matos Maria João,
Vilar Santiago,
Kachler Sonja,
Fonseca André,
Santana Lourdes,
Uriarte Eugenio,
Borges Fernanda,
Tatonetti Nicholas P.,
Klotz KarlNorbert
Publication year - 2014
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201490039
Subject(s) - adenosine receptor , adenosine , receptor , cover (algebra) , coumarin , chemistry , g protein coupled receptor , pharmacology , combinatorial chemistry , computational biology , biochemistry , medicine , biology , agonist , organic chemistry , mechanical engineering , engineering
The back cover picture shows 3‐arylcoumarin analogues targeting A 1 , A 2A , A 2B and A 3 adenosine receptors (ARs). At the cellular level, most of the compounds proved to be selective A 3 AR ligands, which makes them promising development candidates for the treatment of asthma, inflammatory and neurodegenerative diseases, and as protective agents against cardiac ischemia. For more details, see the Full Paper by Maria João Matos et al. on p. 2245 ff.