Premium
Back Cover: Drastic Stabilization of Parallel DNA Hybridizations by a Polylysine Comb‐Type Copolymer with Hydrophilic Graft Chain (ChemMedChem 9/2014)
Author(s) -
Miyoshi Daisuke,
Ueda Yumi,
Shimada Naohiko,
Nakano Shuichi,
Sugimoto Naoki,
Maruyama Atsushi
Publication year - 2014
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201490036
Subject(s) - polylysine , cationic polymerization , copolymer , dna , chemistry , oligonucleotide , polymer chemistry , polymer , combinatorial chemistry , biochemistry , organic chemistry
The back cover picture shows the stabilization of parallel DNA hybrids by a polylysine comb‐type copolymer with a hydrophilic graft chain, which chemically mimics cationic proteins such as histones. The parallel conformations present in DNA duplexes and triplexes are significantly and specifically stabilized by the polymer, indicating that polycationic molecules are able to induce structural polymorphism of DNA oligonucleotides through conformation‐selective stabilization effects. For more details, see the Full Paper by Daisuke Miyoshi, Atsushi Maruyama et al. on p. 2156 ff.