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Inside Back Cover: Dangling Ends Perturb the Stability of RNA Duplexes Responsive to Surrounding Conditions (ChemMedChem 9/2014)
Author(s) -
TateishiKarimata Hisae,
Pramanik Smritimoy,
Nakano Shuichi,
Miyoshi Daisuke,
Sugimoto Naoki
Publication year - 2014
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201490035
Subject(s) - rna , chemistry , dangling bond , nucleotide , cover (algebra) , biophysics , in vitro , stereochemistry , crystallography , biochemistry , biology , silicon , organic chemistry , gene , mechanical engineering , engineering
The inside‐back cover picture shows the importance of unpaired terminal nucleotides (dangling ends) in RNA duplexes. Under cell‐mimicking conditions, the extent to which RNA duplexes with dangling ends are destabilized is dependent on the hydration state of the dangling ends. In contrast, RNA duplexes with dangling ends are stabilized in vitro conditions. It has been postulated that dangling ends alone stabilize helices; however, our results suggest that stabilization is responsive to the surrounding conditions. For more details, see the Full Paper by Naoki Sugimoto et al. on p. 2150 ff.