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Back Cover: 3‐(2‐Oxoethylidene)indolin‐2‐one Derivatives Activate Nrf2 and Inhibit NF‐κB: Potential Candidates for Chemoprevention (ChemMedChem 8/2014)
Author(s) -
Nagle Amrita A.,
Reddy Shridhivya A.,
Bertrand Helene,
Tajima Hisashi,
Dang TruongMinh,
Wong SiewCheng,
Hayes John D.,
Wells Geoffrey,
Chew EngHui
Publication year - 2014
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201490031
Subject(s) - chemistry , nf κb , keap1 , inflammation , cover (algebra) , stereochemistry , pharmacology , signal transduction , cancer research , biochemistry , transcription factor , biology , immunology , mechanical engineering , engineering , gene
The back cover picture shows lead and parent analogues of 3‐(2‐oxopropylidene)indolin‐2‐ones targeting Nrf2‐Keap1 and NF‐κB signaling pathways. At the cellular level, these compounds induce Nrf2‐mediated expression of phase 2 enzymes and suppress NF‐κB‐directed inflammation, which makes them promising development candidates for chemoprevention. For more details, see the Full Paper by Geoffrey Wells, Eng‐Hui Chew et al. on p. 1763 ff.