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Back Cover: 3‐Phenylpropanoic Acid‐Based Phosphotyrosine (pTyr) Mimetics: Hit Evolution to a Novel Orally Active Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitor (ChemMedChem 5/2014)
Author(s) -
Tang YanBo,
Liu JunZheng,
Zhang ShuEn,
Du Xin,
Nie Feilin,
Tian JinYing,
Ye Fei,
Huang Kai,
Hu JinPing,
Li Yan,
Xiao Zhiyan
Publication year - 2014
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201490019
Subject(s) - protein tyrosine phosphatase , chemistry , active site , pharmacokinetics , orally active , in vivo , drug discovery , biochemistry , pharmacology , tyrosine , stereochemistry , enzyme , in vitro , biology , genetics
The back cover picture shows the discovery of a novel orally active PTP1B inhibitor as a potential antidiabetic agent. This potent PTP1B inhibitor was evolved from a previously identified 3‐phenylpropanoic acid‐based hit structure. It showed significant in vivo activity and a suitable pharmacokinetic profile. The results provide a new chemotype of PTP1B inhibitors. For further details, see the Communication by Zhiyan Xiao et al. on p. 918 ff.