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Back Cover: The Di PP ro Approach: Synthesis, Hydrolysis, and Antiviral Activity of Lipophilic d4T Diphosphate Prodrugs (ChemMedChem 4/2014)
Author(s) -
Schulz Tilmann,
Balzarini Jan,
Meier Chris
Publication year - 2014
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201490014
Subject(s) - prodrug , lipophilicity , chemistry , nucleotide , hydrolysis , nucleoside , biochemistry , stereochemistry , gene
The back cover picture shows how a masked precursor of a nucleoside diphosphate (Di PP ro) is taken up by a virus‐infected cell due to its high lipophilicity. Intracellularly, the bioreversible masking units are enzymatically cleaved to the delivery of the diphosphate (B=base, S=sugar, P=phosphate). After conversion into the triphosphate, the nucleotide is able to inhibit viral replication by blocking reverse transcriptase (RT). For further details, see the Full Paper by Chris Meier et al. on p. 762 ff.