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Inside Cover: A Chemical Tool for In Vitro and In Vivo Precipitation of Lysine Methyltransferase G9a (ChemMedChem 3/2014)
Author(s) -
Konze Kyle D.,
Pattenden Samantha G.,
Liu Feng,
BarsyteLovejoy Dalia,
Li Fengling,
Simon Jeremy M.,
Davis Ian J.,
Vedadi Masoud,
Jin Jian
Publication year - 2014
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201490006
Subject(s) - chemistry , lysine , cover (algebra) , in vitro , in vivo , methyltransferase , combinatorial chemistry , nanotechnology , biophysics , biochemistry , materials science , methylation , biology , engineering , dna , microbiology and biotechnology , amino acid , mechanical engineering
The inside cover picture shows chem‐ChIP, a method to examine occupancy of the lysine methyltranferase G9a on chromatin. UNC0965 (green) bridges streptavidin‐coupled magnetic beads (blue and yellow) and G9a (magenta). UNC0965 is cell permeable, which gives chem‐ChIP a distinct advantage over traditional in vitro antibody ChIP. For further details, see the Communication by Jian Jin et al. on p. 549 ff.