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Comparative Cytotoxicity of Artemisinin and Cisplatin and Their Interactions with Chlorogenic Acids in MCF7 Breast Cancer Cells
Author(s) -
Suberu John O.,
RomeroCanelón Isolda,
Sullivan Neil,
Lapkin Alexei A.,
Barker Guy C.
Publication year - 2014
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201402285
Subject(s) - artemisinin , artemisia annua , cytotoxicity , cisplatin , pharmacology , artemisia , in vitro , chemistry , potency , chloroquine , traditional medicine , ic50 , chlorogenic acid , plasmodium falciparum , malaria , medicine , biochemistry , chemotherapy , immunology , food science
In parts of Africa and Asia, self‐medication with a hot water infusion of Artemisia annua ( Artemisia tea) is a common practice for a number of ailments including malaria and cancer. In our earlier work, such an extract showed better potency than artemisinin alone against both chloroquine‐sensitive and ‐resistant parasites. In this study, in vitro tests of the infusion in MCF7 cells showed high IC 50 values (>200 μ M ). The combination of artemisinin and 3‐caffeoylquinic acid (3CA), two major components in the extract, was strongly antagonistic and gave a near total loss of cytotoxicity for artemisinin. We observed that the interaction of 3CAs with another cytotoxic compound, cisplatin, showed potentiation of activity by 2.5‐fold. The chelation of cellular iron by 3CA is hypothesized as a possible explanation for the loss of artemisinin activity.