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Double GC:GC Mismatch in dsDNA Enhances Local Dynamics Retaining the DNA Footprint: A High‐Resolution NMR Study
Author(s) -
Ghosh Anirban,
Kar Rajiv Kumar,
Krishnamoorthy Janarthanan,
Chatterjee Subhrangsu,
Bhunia Anirban
Publication year - 2014
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201402238
Subject(s) - dna , base pair , gene , mutation , genetics , protein data bank (rcsb pdb) , computational biology , molecular dynamics , biology , chemistry , biophysics , stereochemistry , computational chemistry
Mutations in the genome are responsible for several fatal genetic disorders. The default DNA repair mechanism restores the malfunction of the gene caused by mutation to maintain functional regularity and sequential integrity of the cell. Here, we have elucidated the NMR structure and the dynamics of GC mismatched DNA (PDB code: 2MJX) and found that the mismatched DNA still retains the typical B‐type helical form, but in the process introduces backbone distortion resulting from frame‐shifted base pairs.