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DNA Nanostructure‐Based Imaging Probes and Drug Carriers
Author(s) -
Zhan Pengfei,
Jiang Qiao,
Wang Zhengang,
Li Na,
Yu Haiyin,
Ding Baoquan
Publication year - 2014
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201402137
Subject(s) - nanomedicine , nanotechnology , drug delivery , nanostructure , dna nanotechnology , dna , materials science , dna origami , biocompatibility , computational biology , biology , nanoparticle , genetics , metallurgy
Self‐assembled DNA nanostructures are well‐defined nanoscale shapes, with uniform sizes, precise spatial addressability, and excellent biocompatibility. With these features, DNA nanostructures show great potential for biomedical applications; various DNA‐based biomedical imaging probes or payload delivery carriers have been developed. In this review, we summarize the recent developments of DNA‐based nanostructures as tools for diagnosis and cancer therapy. The biological effects that are brought about by DNA nanostructures are highlighted by in vitro and in vivo imaging, antitumor drug delivery, and immunostimulatory therapy. The challenges and perspectives of DNA nanostructures in the field of nanomedicine are discussed.