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Helicases, G4‐DNAs, and Drug Design
Author(s) -
Hale Tracy K.,
Norris Gillian E.,
Jameson Geoffrey B.,
Filichev Vyacheslav V.
Publication year - 2014
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201402068
Subject(s) - helicase , dna , computational biology , drug discovery , dna repair , biology , chemistry , genetics , microbiology and biotechnology , biochemistry , gene , rna
New helicase assays that recognise therapeutically important G4‐DNA structures will lead to the discovery of novel molecular entities that bind not only to G4‐tetrads, but also to grooves and loops of G4‐DNA. Such assays can also provide inhibitors of G4‐specific helicases that will shed light on the emerging involvement of helicases in cancer and other diseases linked to defective DNA repair pathways.