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Back Cover: Synthesis and Biological Evaluation of Imidazopyridine–Oxindole Conjugates as Microtubule‐Targeting Agents (ChemMedChem 12/2013)
Author(s) -
Kamal Ahmed,
Reddy Vangala Santhosh,
Karnewar Santosh,
Chourasiya Sumit S.,
Shaik Anver Basha,
Kumar G. Bharath,
Kishor Chandan,
Reddy M. Kashi,
Narasimha Rao M. P.,
Nagabhushana Ananthamurthy,
Ramakrishna Kallaganti V. S.,
Addlagatta Anthony,
Kotamraju Srigiridhar
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201390054
Subject(s) - imidazopyridine , conjugate , chemistry , oxindole , combinatorial chemistry , microtubule , tubulin , stereochemistry , biochemistry , biology , mathematical analysis , mathematics , microbiology and biotechnology , catalysis
The back cover picture shows the predicted interaction of an imidazopyridine–oxindole conjugate with β‐chain amino acids of tubulin. A series of conjugates were designed, synthesized and evaluated as microtubule‐targeting agents. Molecular modeling predicts that these conjugates bind in the colchicine binding site at the interface between the α‐ and β‐chains of tubulin. For more details, see the Full Paper by Ahmed Kamal, Anthony Addlagatta, Srigiridhar Kotamraju, et al. on p. 2015 ff.