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Inside Cover: Sigma‐2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity (ChemMedChem 12/2013)
Author(s) -
Niso Mauro,
Abate Carmen,
Contino Marialessandra,
Ferorelli Savina,
Azzariti Amalia,
Perrone Roberto,
Colabufo Nicola Antonio,
Berardi Francesco
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201390051
Subject(s) - chemistry , p glycoprotein , collateral damage , receptor , agonist , cancer research , reactive oxygen species , pharmacology , multiple drug resistance , cover (algebra) , biophysics , combinatorial chemistry , medicine , biochemistry , biology , sociology , antibiotics , mechanical engineering , criminology , engineering
The inside cover picture shows a carbazole (compd 25 in the article) interacting with both P‐glycoprotein (P‐gp) and σ 2 receptors. Through these combined activities, a futile ATP cycle is activated and reactive oxygen species (ROS) are generated. Enhanced antiproliferative effects were observed in drug‐resistant over standard MCF7 cells. This phenomenon, termed collateral sensitivity, is under study in multidrug‐ resistant tumors, and mixed σ 2 agonists/P‐gp substrates are promising for their treatment. For more details, see the Full Paper by Carmen Abate et al. on p. 2026 ff.