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Back Cover: Glucosylceramide Mimics: Highly Potent GCase Inhibitors and Selective Pharmacological Chaperones for Mutations Associated with Types 1 and 2 Gaucher Disease (ChemMedChem 11/2013)
Author(s) -
Schönemann Wojciech,
Gallienne Estelle,
IkedaObatake Kyoko,
Asano Naoki,
Nakagawa Shinpei,
Kato Atsushi,
Adachi Isao,
Górecki Marcin,
Frelek Jadwiga,
Martin Olivier R.
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201390049
Subject(s) - glucocerebrosidase , chemical chaperone , chemistry , gaucher's disease , substrate specificity , disease , stereochemistry , computational biology , biology , biochemistry , enzyme , medicine , gene , unfolded protein response
The back cover picture shows the structure of glucocerebrosidase in complex with its substrate, glucosylceramide (GlcCer), and the structure of an iminoglycolipid acting as a mimic of GlcCer. This compound is a very potent inhibitor of glucocerebrosidase and exhibits significant chaperone effect on the N370S and L444P mutations, which are responsible for type 1 and type 2 Gaucher disease, respectively. For more details, see the Full Paper by Olivier R. Martin et al. on p. 1805 ff.