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Inside Cover: A Parallel Semisynthetic Approach for Structure–Activity Relationship Studies of Peptide YY (ChemMedChem 9/2013)
Author(s) -
Albertsen Louise,
Østergaard Søren,
Paulsson Johan F.,
Norrild Jens Chr.,
Strømgaard Kristian
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201390036
Subject(s) - peptide yy , chemistry , native chemical ligation , peptide , stereochemistry , combinatorial chemistry , chemical synthesis , biochemistry , receptor , neuropeptide y receptor , neuropeptide , in vitro
The inside cover picture shows a recombinant thioester fragment (pink tube) of the gut hormone peptide YY (PYY) used in a semisynthetic strategy for the design of C‐terminally modified (blue chemical structure) PYY analogues with potential applications as antiobesity agents. Combining the native chemical ligation–desulfurization approach with a 96‐well plate (background) format allowed rapid parallel generation of PYY analogues that were subsequently tested in cell‐based GPCR (blue cartoon) assays. For more details, see the Full Paper by Jens Chr. Norrild, Kristian Strømgaard et al. on p. 1505 ff.