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Inside Cover: Synthesis and Radiopharmacological Characterisation of a Fluorine‐18‐Labelled Azadipeptide Nitrile as a Potential PET Tracer for in vivo Imaging of Cysteine Cathepsins (ChemMedChem 8/2013)
Author(s) -
Löser Reik,
Bergmann Ralf,
Frizler Maxim,
Mosch Birgit,
Dombrowski Lilli,
Kuchar Manuela,
Steinbach Jörg,
Gütschow Michael,
Pietzsch Jens
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201390031
Subject(s) - nitrile , in vivo , positron emission tomography , chemistry , pet imaging , cathepsin , cysteine , biochemistry , nuclear medicine , enzyme , organic chemistry , medicine , biology , microbiology and biotechnology
The inside cover picture shows a 3D model of an azadipeptide nitrile labeled with fluorine‐18. This compound is capable of targeting cysteine cathepsins, which are implicated in tumor invasion and metastasis, and thereby allows the visualization of these enzymes in vivo by positron emission tomography (PET). For more details, see the Full Paper by Reik Löser et al. on p. 1330 ff.